Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver

Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver

Blog Article

In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis.The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood.This review article aims to provide dorisvale station for sale an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis.Additionally, we describe recent guerlain ideal cologne evidences showing that the role of megakaryocytes in tissue fibrosis is not limited to the bone marrow.